Does the catechol-O-methyltransferase (COMT) Val158Met human polymorphism influence procrastination?

Francesco Di Nocera, Orlando Ricciardi, Georgia Abate, Arturo Bevilacqua

Abstract


Genetic studies are enlightening how the expression of several genes influences neuronal activity and all facets of human normal and abnormal behavior. Among these, a growing body of information shows that a few key genes regulating activity of central neurotransmitters have specific roles in cognitive and/or emotional processes. Examples of these genes are those encoding for the serotonin transporter (5-HTT) and the enzyme cathecol-O-methyltransferase (COMT), both associated with anxiety, aggressive behavior, impulsivity, or even psychopathology. Procrastination is a serious concern in many work and study settings and is usually considered as the expression of impulsive choices: the temporary preference for a smaller-sooner reward over a larger-later reward. Alternatively, but not exclusively, it may be due to the ability to perform better under stressful rather than normal conditions. In the present study, we investigated the association of the 5-HTTLPR and COMT Val158Met polymorphisms with students’ procrastination in an academic writing task. Results showed no relationship between procrastination and the 5-HTT polymorphism but they revealed an association with the COMT Val158Met one. Particularly, the presence of the Met158 allele was found to be significantly associated with the tendency to initiate and complete the assigned task as soon as possible, thus suggesting it may have a protective role in procrastination. Since the 158Met allele provides neurons with significantly higher basal dopamine levels when compared to the 158Val allele, our observation suggests that under normal conditions, namely when the schedule deadline is far ahead, the 158Met allele provides carriers with increased inhibitory control and/or cognitive performance, resulting in an increased tendency to adhere to a planned schedule and therefore reducing procrastination. On the other hand, the Val158 allele may result more effective in increasing carriers’ performances under stress conditions, namely when the schedule deadline is approaching, and dopamine release is increased. This would result in a higher tendency to procrastinate.

 

 

 

 


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Anderson, DE, Bell, TA, & Awh, E, 2012, Polymorphisms in the 5-HTTLPR gene mediate storage capacity of visual working memory, Journal of cognitive neuroscience, vol 24, n. 5, 1069. doi:10.1162/jocn_a_00207

Basay, BK, Buber, A, Basay, O, Alacam, H, Ozturk, O, Suren, S, ... & Ercan, ES, 2016, White matter alterations related to attention-deficit hyperactivity disorder and COMT val158met polymorphism: children with valine homozygote attention-deficit hyperactivity disorder have altered white matter connectivity in the right cingulum (cingulate gyrus), Neuropsychiatric disease and treatment, vol 12, pag. 969. doi:10.2147/NDT.S104450

Benedetti, F, Dallaspezia, S, Colombo, C, Lorenzi, C, Pirovano, A, & Smeraldi, E, 2010, Association between catechol-O-methyltransferase Val (108/158) Met polymorphism and psychotic features of bipolar disorder, Journal of affective disorders, vol 125, n. 1, pag. 341-344. doi:10.1016/j.jad.2010.01.005

Bevilacqua, L, & Goldman, D, 2013, Genetics of impulsive behaviour, Philosophical Transactions of the Royal Society of London B: Biological Sciences, vol 368, pag. 1615, 20120380. doi:10.1098/rstb.2012.0380

Bilder, RM, Volavka, J, Lachman, HM, & Grace, AA, 2004, The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes, Neuropsychopharmacology, vol 29, n. 11. doi:10.1038/sj.npp.1300542

Boettiger, CA, Mitchell, JM, Tavares, VC, Robertson, M, Joslyn, G, D'Esposito, M, Fields, HL, 2007, Immediate reward bias in humans: fronto-parietal networks and a role for the catechol-O-methyltransferase 158(Val/Val) genotype, Journal of Neuroscience, vol 27, n. 52, pag. 14383-14391. doi:10.1523/JNEUROSCI.2551-07.2007

Borg, J, Henningsson, S, Saijo, T, Inoue, M, Bah, J, Westberg, L, ... & Halldin, C, 2009, Serotonin transporter genotype is associated with cognitive performance but not regional 5-HT1A receptor binding in humans, International Journal of Neuropsychopharmacology, vol 12, n. 6, pag. 783-792. doi:10.1017/S1461145708009759

Britton, BK, & Tesser, A, 1991, Effects of time-management practices on college grades, Journal of educational psychology, vol 83, n. 3, pag. 405. doi:10.1037/0022-0663.83.3.405

Brotman, MA, Schmajuk, M, Rich, BA, Dickstein, DP, Guyer, AE, Costello, EJ, ... & Leibenluft, E, 2006, Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children, Biological Psychiatry, vol 60, n. 9, pag. 991-997. doi:10.1016/j.biopsych.2006.08.042

Brown, GL, Ebert, MH, Goyer, PF, Jimerson, DC, Klein, WJ, Bunney, WE, & Goodwin, FK, 1982, Aggression, suicide, and serotonin: Relationships of CSF amine metabolites, The American Journal of Psychiatry, vol 139, n. 6, pag. 741-746.

Bruder, GE, Keilp, JG, Xu, H, Shikhman, M, Schori, E, Gorman, JM, & Gilliam, TC, 2005, Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations, Biological Psychiatry, vol 58, pag. 901-907. doi:10.1016/j.biopsych.2005.05.010

Bullock, R, & Saharan, A, 2002, Atypical antipsychotics: experience and use in the elderly, International journal of clinical practice, vol 56, n. 7, pag. 515-525.

Chen, J, Lipska, BK, Halim, N, Ma, QD, Matsumoto, M, Melhem, S, ... & Egan, MF, 2004, Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain, The American Journal of Human Genetics, vol 75, n. 5, pag. 807-821. doi:10.1086/425589

Coletta, S, Polzella, D, & Di Nocera, F, 2010, Time Management Behavior Scale: Adattamento alla lingua italiana e considerazioni sulla sua dimensionalità, Rivista di Ergonomia, vol 2, pag. 31-40.

Collier, DA, Stöber, G, Li, T, Heils, A, Catalano, M, Di Bella, D, & Müller, CR, 1996, A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders, Molecular psychiatry, vol 1, n. 6, pag. 453-460.

Congdon, E, & Canli, T, 2008, A neurogenetic approach to impulsivity, Journal of personality, vol 76, n. 6, pag. 1447-1484. doi:10.1111/j.1467-6494.2008.00528.x

da Rocha, FF, Malloy-Diniz, L, Lage, NV, Romano-Silva, MA, de Marco, LA, & Correa, H, 2008, Decision-making impairment is related to serotonin transporter promoter polymorphism in a sample of patients with obsessive–compulsive disorder, Behavioural brain research, vol 195, n. 1, pag. 159-163. doi:10.1016/j.bbr.2008.05.015

Dingemanse, NJ, & Réale, D, 2005, Natural selection and animal personality, Behaviour, vol 142, n. 9-10, pag. 1159-1184. doi:10.1163/156853905774539445

Di Nocera, F, Colazingari, S, Trabalza, A, Mamazza, L, & Bevilacqua, A, 2014, Association of TPH2 and dopamine receptor gene polymorphisms with obsessive-compulsive symptoms and perfectionism in healthy subjects, Psychiatry research, vol 220, n. 3, pag. 1172. doi:10.1016/j.psychres.2014.09.015

Egan, MF, Goldberg, TE, Kolachana, BS, Callicott, JH, Mazzanti, CM, Straub, RE, ... & Weinberger, DR, (2001), Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia, Proceedings of the National Academy of Sciences, vol 98, n. 12, pag. 6917-6922. doi:10.1073/pnas.111134598

Eisenberg, Dan TA, & Hayes, MG, 2010, Testing the null hypothesis: comments on ‘Culture-gene coevolution of individualism-collectivism and the serotonin transporter gene’, Proc. Biol. Sci., vol 278, n. 1704, pag. 329–332. doi: 10.1098/rspb.2010.0714

Forbes, EE, Brown, SM, KimakM, Ferrell, RE, Manuck, SB, & Hariri, AR, 2009, Genetic variation in components of dopamine neuro- transmission impacts ventral striatal reactivity associated with impulsivity, Molecular Psychiatry, vol 14, pag. 60-70. doi:10.1038/sj.mp.4002086

George, D, Dixon, S, Stansal, E, Gelb, SL, & Pheri, T, 2008, Time diary and questionnaire assessment of factors associated with academic and personal success among university undergraduates, Journal of American College Health, vol 56, n. 6, pag. 706-715. doi:10.3200/JACH.56.6.706-715

Gerra, G, Garofano, L, Santoro, G, Bosari, S, Pellegrini, C, Zaimovic, A, ... & Donnini, C, 2004, Association between low‐activity serotonin transporter genotype and heroin dependence: Behavioral and personality correlates, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol 126, n. 1, pag. 37-42. doi:10.1002/ajmg.b.20111

Green, KE, 1997, Psychosocial factors affecting dissertation completion, New Directions for Higher Education, vol 1997, n. 99, pag. 57-64. doi:10.1002/he.9905

Gunthert, KC, Conner, TS, Armeli, S, Tennen, H, Covault, J, & Kranzler, HR, 2007, Serotonin transporter gene polymorphism (5-HTTLPR) and anxiety reactivity in daily life: A daily process approach to gene-environment interaction, Psychosomatic medicine, vol 69, n. 8, pag. 762-768. doi:10.1097/PSY.0b013e318157ad42

Gustavson, DE, Miyake, A, Hewitt, J, Friedman, NP, 2014, Genetic relations among procrastination, impulsivity, and goal-management ability implications for the evolutionary origin of procrastination, Psychological Science, vol 25, n. 6, pag. 1178-88. doi:10.1177/0956797614526260

Heinz, A, Smolka, MN, 2006, The effects of catechol O-methyltransferase genotype on brain activation elicited by affective stimuli and cognitive tasks, Rev. Neurosci., vol 17, n. 3, pag. 359-67. doi:10.1515/REVNEURO.2006.17.3.359

Han, DH, Kee, BS, Min, KJ, Lee, Y, S, Na, C, Park, DB, Lyoo, IK, 2006, Effects of catechol-O-methyltransferase Val158Met polymorphism on the cognitive stability and aggression in the first-onset schizophrenic patients, Neuroreport, vol 17, n. 1, 95-99.

Heils, A, Teufel, A, Petri, S, Stöber, G, Riederer, P, Bengel, D, & Lesch, KP, 1996, Allelic variation of human serotonin transporter gene expression, Journal of neurochemistry, vol 66, n. 6, pag. 2621-2624. doi:10.1046/j.1471-4159.1996.66062621.x

Hu, XZ, Lipsky, RH, Zhu, G, Akhtar, LA, Taubman, J, Greenberg, BD, Xu, K, Arnold, PD, Richter, MA, Kennedy, JL, Murphy, DL, Goldman, D, 2006, Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder, The American Journal of Human Genetics, vol 78, n. 5, pag. 815-826. doi:10.1086/503850

Jacob, C, Strobel, A, Hohenberger, K, Ringel, T, Gutknecht, L, Reif, A, Brocke, B, & Lesch, K, 2004, Association between allelic variation of serotonin transporter function and neuroticism in anxious cluster C personality disorders, American Journal of Psychiatry, vol 161, pag. 569–572. doi:10.1176/appi.ajp.161.3.569

Joober, R, Gauthier, J, Lal, S, Bloom, D, Lalonde, P, Rouleau, G, ... & Labelle, A, 2002, Catechol-O-methyltransferase Val-108/158-Met gene variants associated with performance on the Wisconsin Card Sorting Test, Archives of General Psychiatry, vol 59, n. 7, pag. 662-663. doi:10.1001/archpsyc.59.7.662

Kim, KR, & Seo, EH, 2015, The relationship between procrastination and academic performance: A meta-analysis, Personality and Individual Differences, vol 82, pag. 26-33. doi:10.1016/j.paid.2015.02.038

Lachman, HM, Papolos, DF, Saito, T, Yu, YM, Szumlanski, CL, & Weinshilboum, RM, 1996, Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders, Pharmacogenetics and Genomics, vol 6, n. 3, pag. 243-250.

Lage, GM, Malloy-Diniz, LF, Matos, LO, Bastos, MA, Abrantes, SS, & Corrêa, H, 2011, Impulsivity and the 5-HTTLPR polymorphism in a non-clinical sample, PLoS One, vol 6, n. 2, e16927. doi:10.1371/journal.pone.0016927

Landrø, NI, Jonassen, R, Clark, L, Haug, KF, Aker, M, Bø, R, ... & Stiles, TC, 2015, Serotonin transporter polymorphisms predict response inhibition in healthy volunteers, Neuroscience letters, vol 584, pag. 109-112. doi:10.1016/j.neulet.2014.10.006

Lee, LO, & Prescott, CA, 2014, Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits: a meta-analysis, Psychiatr Genet., vol 24, n. 2, pag. 52-69. doi: 10.1097/YPG.0000000000000018

Macan, TH, Shahani, C, Dipboye, RL, & Phillips, AP, 1990, College students' time management: Correlations with academic performance and stress, Journal of educational psychology, vol 82, n. 4, pag. 760. doi:10.1037/0022-0663.82.4.760

Malhotra, AK, Kestler, LJ, Mazzanti, C, Bates, JA, Goldberg, T, & Goldman, D, 2002, A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition, American Journal of Psychiatry, vol 159, n. 4, pag. 652-654. doi:10.1176/appi.ajp.159.4.652

Mannisto PT, Kaakkola S, 1999, Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors, Pharmacological Reviews, vol 51, n. 4, pag. 593–628.

Nakamura, M, Ueno, S, Sano, A, & Tanabe, H, 2000, The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants, Molecular Psychiatry, vol 5, n. 1, pag. 32-38. doi:10.1038/sj.mp.4000698

Nedic, G, Nikolac, M, Sviglin, KN, Muck-Seler, D, Borovecki, F, Pivac, N, 2011, Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence, International Journal of Neuropsychopharmacology, vol 14, n. 3, pag. 377-388. doi:10.1017/S1461145710001057.

Niehaus, DJH, Kinnear, CJ, Corfield, VA, Du Toit, PL, Van Kradenburg, J, Moolman-Smook, JC, ... & Knowles, JA, 2001, Association between a catechol-O-methyltransferase polymorphism and obsessive–compulsive disorder in the Afrikaner population, Journal of affective disorders, vol 65, n. 1, pag. 61-65. doi:10.1016/S0165-0327(00)00246-9

Nomura, M, Kaneko, M, Okuma, Y, Nomura, J, Kusumi, I, Koyama, T, & Nomura, Y, 2015, Involvement of serotonin transporter gene polymorphisms (5-HTT) in impulsive behavior in the japanese population, PloS one, vol 10, n. 3, e0119743, doi:10.1371/journal.pone.0119743

Paaver, M, Nordquist, N, Parik, J, Harro, M, Oreland, L, & Harro, J, 2007, Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing, Psychopharmacology, vol 194, n. 4, pag. 545-554. doi:10.1007/s00213-007-0867-z

Palmatier, MA, Kang, AM, & Kidd, KK, 1999, Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles, Biological Psychiatry, vol 46, n. 4, pag. 557-567. doi:10.1016/S0006-3223(99)00098-0

Perry, RP, Hladkyj, S, Pekrun, RH, Clifton, RA, & Chipperfield, JG, 2005, Perceived academic control and failure in college students: A three-year study of scholastic attainment, Research in Higher Education, vol 46, n. 5, pag. 535-569. doi:10.1007/s11162-005-3364-4

Pivac, N, Pregelj, P, Nikolac, M, Zupanc, T, Nedic, G, Muck Seler, D, & Videtic Paska, A, 2011, The association between catechol‐O‐methyl‐transferase Val108/158Met polymorphism and suicide, Genes, brain and behavior, vol 10, n. 5, pag. 565-569. doi:10.1111/j.1601-183X.2011.00695.x

Rotondo, A, Mazzanti, C, Dell'Osso, L, Rucci, P, Sullivan, P, Bouanani, S, ... & Cassano, GB, 2002, Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder, American Journal of Psychiatry, vol 159, n. 1, pag. 23-29. doi:10.1176/appi.ajp.159.1.23

Rudnick, G, Clark, J, 1993, From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters, Biochemica Biophysica Acta, vol 1144, pag. 249–63. doi:10.1016/0005-2728(93)90109-S

Rujescu, D, Giegling, I, Gietl, A, Hartmann, AM, & Möller, HJ, 2003, A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits, Biological psychiatry, vol 54, n. 1, pag. 34-39. doi:10.1016/S0006-3223(02)01831-0

Salatino-Oliveira, A, Genro, JP, Guimaraes, AP, Chazan, R, Zeni, C, Schmitz, M, ... & Hutz, MH, 2012, Cathechol-O-methyltransferase Val 158 Met polymorphism is associated with disruptive behavior disorders among children and adolescents with ADHD, Journal of Neural Transmission, vol 119, n. 6, pag. 729-733. doi:10.1007/s00702-012-0766-2

Smolka, MN, Schumann, G, Wrase, J, Grüsser, SM, Flor, H, Mann, K, Braus, DF, Goldman, D, Büchel, C, & Heinz, A, 2005, Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex, J Neurosci., vol 25, n. 4, pag. 836-42. doi:10.1523/JNEUROSCI.1792-04.2005

Soeiro-De-Souza, MG, Stanford, MS, Bio, DS, Machado-Vieira, R, Moreno, RA, 2013, Association of the COMT Met¹⁵⁸ allele with trait impulsivity in healthy young adults, Molecular Medicine Reports, vol 7, n. 4, pag. 1067-1072. doi: 10.3892/mmr.2013.1336

Steel, P, 2007, The nature of procrastination: a meta-analytic and theoretical review of quintessential self-regulatory failure, Psychological bulletin, vol 133, n. 1, 65. doi:10.1037/0033-2909.133.1.65

Strobel, A, Dreisbach, G, Müller, J, Goschke, T, Brocke, B, & Lesch, KP, 2007, Genetic variation of serotonin function and cognitive control, Journal of Cognitive Neuroscience, vol 19, n. 12, pag. 1923-1931. doi:10.1162/jocn.2007.19.12.1923

Strous, RD, Nolan, KA, Lapidus, R, Diaz, L, Saito, T, & Lachman, HM, 2003, Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: a replication study, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol 120, n. 1, pag. 29-34. doi:10.1002/ajmg.b.20021

Tunbridge, EM, Harrison, PJ, Weinberger, DR, 2006, Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond, Biol Psychiatry, vol 60, n. 2, pag. 141-51. doi:10.1016/j.biopsych.2005.10.024

Walderhaug, E, Herman, AI, Magnusson, A, Morgan, MJ, & Landrø, NI, 2010, The short (S) allele of the serotonin transporter polymorphism and acute tryptophan depletion both increase impulsivity in men, Neuroscience Letters, vol 473, n. 3, pag. 208-211. doi:10.1016/j.neulet.2010.02.048

Wilson, K, & Narayan, A, 2016, Relationships among individual task self-efficacy, self-regulated learning strategy use and academic performance in a computer-supported collaborative learning environment, Educational Psychology, vol 36, n. 2, pag. 236-253. doi:10.1080/01443410.2014.926312


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